Martin Luther University Halle-Wittenberg

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Biomedical Materials Group - Research Projects

Project sponsored by Saxony-Anhalt

Power center "Chemical and Biosystem Technics"

Collaborative projects within the program

Saxony-Anhalt SCIENCE

Focus on the subject

Functional molecules from renewable resources

The subproject CBS 7

DESIGN OF BIOACTIVE SURFACE COATINGS AND HYDROGELS FOR MEDICAL APPLICATIONS BASED ON BIOBASED MATERIALS

Runtime: October 1st, 2016 to September 30th, 2019

Coordinator: Dr. rer. nat Alexandros Repanas

Biobased materials such as alginates, cellulose, chitosan and hyaluronans should receive bioactivity through specific chemical reaction that allows their medical use. The bioactivity of polysaccharides is determined by adsorptive or covalent coupling to polymers, ceramics and metals or as cross-linking in situ hydrogels with cell cultures, making new products for medical implants and cell therapy to be selected.

DFG project 2016

In situ gelling hydrogels for cartilage regeneration

Runtime: June 1st, 2016 to May 31st, 2019

Coordinator: Dr. rer. nat. Andrea Liedmann

In situ cross-linking hydrogels are useful for minimal invasive treatment of tissue defects and also for controlled release of drugs. The proposal is focused on the hypothesis that semisynthetic sulfated and oxidized polysaccharides like cellulose and chitosan can be used for generation of hydrogels with tunable mechanical properties, degradation behavior, kinetic of release of growth factor TGF-beta3 and resulting chondrogenic activity towards mesenchymal stem cells to be applicable for regeneration of cartilage. Beside synthesis of cellulose and chitosan derivatives, characterization of mechanical degradation properties and in vitro studies on bioactivity, also spectroscopic and imaging methods shall be used to analyze mass transfer inside hydrogels, mechanical properties, and biocompatibility in vitro and in vivo with a mouse model.

German Research Society (DFG) through Grant GR 1290/11-1

EU Joint Mobility Project - BEAM

Biomedical Engineering - EU Australian cooperation at the master level

Runtime: October 1st, 2014 to September 30th, 2017

Coordinator: Prof. T. Groth

The Martin Luther University Halle-Wittenberg is a member of a project funded by the European Union, which promotes the exchange of students between Europe and Australia. German students can take courses in the fields of biomedical engineering and pharmacy for 3.5 or 5 months at the Queensland University of Technology in Brisbane or the University of Sydney, and at the same time, in consultation with the Biomedical Materials Group and their colleagues in Australia, prepare a Master or Diploma Thesis.

http://www.beam-jmp.eu   

EU-IAPP project

Network for development of soft nanofibrous construct for cellular therapy of degenerative skeletal disorders

Runtime: January 1st, 2013 to December 31st, 2016

Coordinator: Prof. G. Altankov, ICREA & Institute for Bioengineering of Catalonia (IBEC)

High incidence of degenerative skeletal tissue disorders in a progressively aging human population make tissue engineering of cartilage and bone a focus of extensive research. Bone and joint disorders are the most  common disease in Europe: More than 100 million European citizens suffer  from arthritis and 19 million people have osteoporosis (one of three women and one of eight men are affected). This project is designed to  supplement the existing EuroNanoMed project aimed to develop an innovative strategy for targeting bone and cartilage regeneration. More specifically the project seeks to set up an international multidisciplinary team of young scientists and engineers representing both academia and industry partners that will strongly contribute to the design of a novel type of implant, which can strongly promote tissue regeneration combining high performance materials, advanced nanotechnology and living cells.

http://www.fibrogelnet.org   

DFG project 2013

Effects of the combination of nanostructuring and multilayers of polyelectrolytes on the differentiation of stem cells

Runtime: May 1st, 2013 to July 31st, 2017

Coordinator: Dr.-Ing. Marcus S. Niepel

The extracellular matrix is a substrate that combines chemical stimuli with specific mechanical properties in a 3D environment at the nanoscale, through which cellular response is controlled. The aim of the proposed project is the elucidation of the influence of nanostructured substrates with specific viscoelastic properties on adhesion, growth and differentiation of the murine mesenchymal stem cell line C3H/10T1/2. Tetrahedral gold structures of defined size and spacing are designed on planar model surfaces using the nanosphere lithography (NSL) and subsequently modified with the layer-by-layer (LbL) technique to introduce a system of defined viscoelasticity. Since both the size and number of focal adhesions, which are regulated by the structure dimensions, as well as the mechanical properties of substrate have an impact on the behavior of cells, several effects are expected that influence adhesion growth and differentiation of cells and that shall be investigated using molecular biological methods. In this way, we can draw conclusions on the influence of topographic and viscoelastic surface characteristics on stem cell behavior that are of interest for the development of new biomaterials for tissue engineering and regenerative medicine.

German Research Society (DFG) through Grant GR 1290/10-1

Data Bank of the Federal State of Saxony-Anhalt (Germany)

Forschungsdatenbank des Landes Sachsen-Anhalt

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